1.学习和工作经历 2020年10月—现在： 广东省第二人民医院,研究员、首席科学家 1998年12月-2020年9月 中国科学院动物研究所,研究员 1996年9月-1998年12月 中国科学院动物研究所,副研究员 1998年12月-2020年9月 中国科学院研究生院、中国科学院大学,教授、岗位教授 2002年1月-2006年12月 中国科学院动物研究所生殖发育与衰老研究中心,主任 2002年11月-2006年10月 计划生育生殖生物学国家重点实验室,常务副主任 2026年11月-2011年11月 计划生育生殖生物学国家重点实验室,主任 2009年4月-2009年7月 University of Missouri-Columbia，USA,高级研究学者 2008年4月-2008年6月 National Institute of Agrobiological Sciences，Japan, Invited Short-Term JAPS Fellow 2005年5月-2005年8月 University of Missouri-Columbia，USA,高级研究学者 2003年3月-2003年4月 National Institute of Agrobiological Sciences，Japan, Invited Short-Term JAPS Fellow 1999年10月-2001年8月 University of Missouri-Columbia, USA, Research associate 1996年1月－1996年4月 National Institute of Animal Industry, Japan, STA Fellow 1996年10月－1998年4月 Bar-Ilan University, Israel,博士后 1994年8月－1996年8月 中国科学院动物研究所计划生育生殖生物学国家重点实验室,博士后 1991年8月－1994年6月 东北农业大学生物工程系,博士研究生 1988年7月－1991年7月 山东农业大学畜牧兽医系,助教 1985年7月－1988年6月 东北农业大学生物工程系,硕士研究生 1981年9月－1985年6月 山东农业大学畜牧兽医系,本科生
3.主要社会任职 国务院学位委员会第六届学科评议组生物学组成员（2009-2013） 中国动物学会副理事长（2009--2019）、副监事长（2024--） 中国动物学会生殖生物学分会主任委员（2013--2019） 中国动物学会细胞及分子显微技术分会主任委员(2003--2014) 中国解剖学会医学发育生物学分会副主任委员（2014--2022） 世界生殖生物学联合组织，中方代表（2011--2020） Biology of Reproduction，编委（2007-2017） Molecular Human Reproduction，副主编（2016—2020） Journal of Genetics and Genomics，副主编（2017—2020）、编委（2013---2016；2020-现在） Molecular Reproduction and Development，副主编（2007-2008）、编委（2014—现在） Reproduction, Fertility and Development，副主编（2009-2017） Cell Cycle，编委（2007-现在） Journal of Reproduction and Development，编委（2004-现在） Asian Journal of Andrology，编委（2004—2015） Current Zoology，副主编（2009—2016）、编委（2016—现在） Progress in Biochemistry and Biophysics，编委（2010—现在） Reproductive and Developmental Medicine，副总编（2017—现在） Reproductive Toxicology, 编委（2021—现在） Journal of Animal Reproduction and Biotechnology, 编委（2021—现在） Progress in Natural Science，编委（2004—2008） 遗传，副主编（2010—2013） 动物学报，编委（1999—2008） 动物学杂志，编委（1999—现在） 生殖医学杂志，编委（2002—2015） 细胞生物学杂志，编委（2007—2009） 中国细胞生物学报，编委（2010—2020） 生殖与避孕杂志，副主编（2012—2016）
5.近5年发表的主要论文(*通讯作者) Li C#, Tan YP#, Gao D#, Su R#, Xu K, Liu SC, Li XF, Lu YH, Yi LT, Wang G, Ou XH*, Meng TG*, Sun QY*. IRE1α RNase activity is critical for early embryo development by degrading maternal transcripts. Nucleic Acids Res. 2025 Jun 6;53(11):gkaf520. doi: 10.1093/nar/gkaf520.
Zhao ZH#, Meng TG#, Chen XY, Gao F, Schatten H, Ou XH*, Sun QY*. Spatiotemporal and single-cell atlases to dissect regional specific cell types of the developing ovary. Commun Biol. 2025 Jun 3;8(1):849. doi: 10.1038/s42003-025-08277-4.
Guo HY#, Tang SB#, Li LJ#, Lin J, Zhang TT, Chao S, Jin XW, Xu KP, Su XF, Yin S, Zhao MH, Huang GA, Yang LJ, Shen W, Zhang L, Zhang CL*, Sun QY*, Ge ZJ*. Gestational diabetes mellitus causes genome hyper-methylation of oocyte via increased EZH2. Nat Commun. 2025 Jan 2;16(1):127. doi: 10.1038/s41467-024-55499-x.
Gao D#, Li C#, Liu SY#, Xu TT#, Lin XT, Tan YP, Gao FM, Yi LT, Zhang JV, Ma JY, Meng TG, Yeung WSB, Liu K, Ou XH*, Su RB*, Sun QY*. P300 regulates histone crotonylation and preimplantation embryo development. Nat Commun. 2024 Jul 30;15(1):6418. doi: 10.1038/s41467-024-50731-0.
Zhou C#*, Zhang X#, Xu G#, Ran Y#, Wang H#, Xie X, Li A, Li F, Li X, Ding J, Zhang M, Sun QY*, Ou XH*. A microtubule-associated protein functions in preventing oocytes from evading the spindle assembly checkpoint. Adv Sci (Weinh). 2024 Dec 25:e2413097. doi: 10.1002/advs.202413097.
Wang L, Liu C, Li L, Wei H, Wei W, Zhou Q, Chen Y, Meng TG, Jiao R, Wang ZB*, Sun QY*, Li W*. RNF20 Regulates oocyte meiotic spindle assembly by recruiting TPM3 to centromeres and spindle poles. Adv Sci (Weinh). 2024 Jan 19:e2306986. doi: 10.1002/advs.202306986.
Chao S, Lu J, Li LJ, Guo HY, Xu K, Wang N, Zhao SX, Jin XW, Wang SG, Yin S, Shen W, Zhao MH, Huang GA, Sun QY*, Ge ZJ*. Maternal obesity may disrupt offspring metabolism by inducing oocyte genome hyper-methylation via increased DNMTs. eLife. 2024 Dec 6;13:RP97507. doi: 10.7554/eLife.97507
Sun SM, Zhao BW, Li YY, Liu HY, Xu YH, Yang XM, Guo JN, Ouyang YC, Weng CJ*, Guan YC*, Sun QY*, Wang ZB*. Loss of UBE2S causes meiosis I arrest with normal spindle assembly checkpoint dynamics in mouse oocytes. Development. 2024 Mar 15;151(6):dev202285. doi: 10.1242/dev.202285.
Dong MZ, Ouyang YC, Gao SC, Gu LJ, Guo JN, Sun SM, Wang ZB, Sun QY*. Protein phosphatase 4 maintains the survival of primordial follicles by regulating autophagy in oocytes. Cell Death Dis. 2024 Sep 8;15(9):658. doi: 10.1038/s41419-024-07051-4.
Yue W, Zhang HY, Schatten H, Meng TG, Sun QY*. CtIP regulates G2/M transition and bipolar spindle assembly during mouse oocyte meiosis. J Genet Genomics. 2024 Dec;51(12):1435-1446.
Gu LJ#, Li L#, Li QN, Xu K, Yue W, Qiao JY, Meng TG, Dong MZ, Lei WL, Guo JN, Wang ZB, Sun QY*. The transgenerational effects of maternal low-protein diet during lactation on offspring. J Genet Genomics. 2024 Apr 22:S1673-8527(24)00079-1. doi: 10.1016/j.jgg.2024.04.008.
Meng TG#, Guo JN#, Zhu L#, Yin Y#, Wang F, Han ZM, Lei L, Ma XS, Xue Y, Yue W, Nie XQ, Zhao ZH, Zhang HY, Sun SM, Ouyang YC, Hou Y, Schatten H, Ju Z, Ou XH*, Wang ZB*, Wong CCL*, Li Z*, Sun QY*. NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition. Adv Sci (Weinh). 2023 Jul 26:e2301940. doi: 10.1002/advs.202301940.
Qiao JY, Zhou Q, Xu K, Yue W, Lei WL, Li YY, Gu LJ, Ouyang YC, Hou Y, Schatten H, Meng TG*, Wang ZB*, Sun QY*, Mad2 is dispensable for accurate chromosome segregation but becomes essential when oocytes are subjected to environmental stress. Development. 2023 Jul 15;150(14):dev201398. doi: 10.1242/dev.201398.
Lei WL#, Du Z#, Meng TG#, Su R#, Li YY, Liu W, Sun SM, Liu MY, Hou Y, Zhang CH, Gui Y, Schatten H, Han Z, Liu C, Sun F*, Wang ZB*, Qian WP*, Sun QY*. SRSF2 is required for mRNA splicing during spermatogenesis. BMC Biol. 2023 Oct 23;21(1):231. doi: 10.1186/s12915-023-01736-6.
Tang SB, Zhang TT, Yin S, Shen W, Luo SM, Zhao Y, Zhang CL, Klinger FG, Sun QY*, Ge ZJ*. Inheritance of perturbed methylation and metabolism caused by uterine malnutrition via oocytes. BMC Biol. 2023 Feb 24;21(1):43. doi: 10.1186/s12915-023-01545-x.
Zhou Q, Xu K, Zhao BW, Qiao JY, Li YY, Lei WL, Li J, Ouyang YC, Hou Y, Schatten H, Wang ZB, Sun QY*. Mitochondrial E3 ubiquitin ligase MARCH5 is required for mouse oocyte meiotic maturation. Biol Reprod. 2023 Mar 13;108(3):437-446. doi: 10.1093/biolre/ioac215.
Gao D, Wang X, Yan YL, Li C, Tan YP, Liu QC, Zhang MY, Zhang JV, Sun QY*, Cao ZB*, Zhang YH*. CircKDM5B sponges miR-128 to regulate porcine blastocyst development by modulating trophectoderm barrier function. Mol Hum Reprod. 2023 Jul 20:gaad027. doi: 10.1093/molehr/gaad027.
Li C, Tan YP, Ma XS, Wang ZB, Meng TG*, Sun QY*. CDT1 is the major functional regulatory subunit of the pre-replication complex in zygotes. Cell Prolif. 2023 Mar;56(3):e13377. doi: 10.1111/cpr.13377
Chen L, Ouyang YC, Gu LJ, Guo JN, Han ZM, Wang ZB, Sun QY*. Septin 9 controls CCNB1 stabilization via APC/CCDC20 during meiotic metaphase I/anaphase I transition in mouse oocytes. Cell Prolif. 2023 Feb;56(2):e13359. doi: 10.1111/cpr.13359.
Zhou CJ, Wang XY, Dong YH, Wang DH, Han Z, Zhang XJ, Sun QY, Carroll J, Liang CG. CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I. Nat Commun. 2022 Dec 13;13(1):7732. doi: 10.1038/s41467-022-35461-5.
Dong MZ, Ouyang YC, Gao SC, Ma XS, Hou Y, Schatten H, Wang ZB*, Sun QY*. PPP4C facilitates homologous recombination DNA repair by dephosphorylating PLK1 during early embryo development. Development. 2022 May 12:dev.200351. doi: 10.1242/dev.200351.
Fan XY, Guo L, Chen LN, Yin S, Wen J, Li S, Ma JY, Jing T, Jiang MX, Sun XH, Chen M, Wang F, Wang ZB, Zhang CF, Wang XH, Ge ZJ, Hu C, Zeng L, Shen W, Sun QY*, Ou XH*, Luo SM*. Reduction of mtDNA heteroplasmy in mitochondrial replacement therapy by inducing forced mitophagy. Nat Biomed Eng. 2022 Apr 18. doi: 10.1038/s41551-022-00881-7
Yue W, Wang Y, Meng TG, Zhang HY, Zhang XR, Ouyang YC, Hou Y, Schatten H, Wang ZB*, Sun QY*, Kinetochore scaffold 1 regulates SAC function during mouse oocyte meiotic maturation. FASEB J, 2022 Mar;36(3):e22210. doi: 10.1096/fj.202101586RR
Liu W, Lu X, Zhao ZH, Su R, Li QL, Xue Y, Gao Z, Sun SS, Lei WL, Li L, An G, Liu H, Han Z, Ouyang YC, Hou Y, Wang ZB*, Sun QY*, Liu J*. SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing. eLife. 2022 Nov 10;11:e78211. doi: 10.7554/eLife.78211.PMID: 36355419 . Chen L, Ouyang YC, Gu LJ, Guo JN, Han ZM, Wang ZB, Sun QY*. Septin 9 controls CCNB1 stabilization via APC/CCDC20 during meiotic metaphase I/anaphase I transition in mouse oocytes. Cell Prolif. 2022 Nov 10:e13359. doi: 10.1111/cpr.13359.
Su R#, Fan LH#, Cao C#, Wang L, Du Z, Cai Z, Ouyang YC, Wang Y, Zhou Q, Wu L, Zhang N, Zhu X, Lei WL, Zhao H, Tian Y, He S, Wong CCL*, Sun QY*, Xue Y*. Global profiling of RNA-binding protein target sites by LACE-seq. Nat Cell Biol. 2021 Jun;23(6):664-675. doi: 10.1038/s41556-021-00696-9.
Zhu FZ#, Wang LL#, Meng TG#, Wang RL#, Yang ZX#, Cao Y, Zhu GY, Jin Z, Gao LL, Zeng WT, Wang ZB*, Sun QY*, Zhang D*, Inhibiting bridge integrator 2 phosphorylation leads to improved oocyte quality, ovarian health and fertility in aging and after chemotherapy in mice. Nat Aging 2021, 1 1010–1023.
Zhao ZH, Meng TG, Zhang HY, Hou Y, Schatten H, Wang ZB, Sun QY*. Single cell RNA sequencing reveals species-specific time spans of cell cycle transitions in early oogenesis. Hum Mol Genet. 2021 Feb 11:ddab048. doi: 10.1093/hmg/ddab048.
Chen LJ, Zhang NN, Zhou CX, Yang ZX, Li YR, Zhang T, Li CR, Wang X, Wang Y, Wang ZB, Xia ZR, Wang ZB, Zhang CL*, Guan YC*, Sun QY*, Zhang D*. Gm364 coordinates MIB2/DLL3/Notch2 to regulate female fertility through AKT activation. Cell Death Differ. 2021 Oct 11. doi: 10.1038/s41418-021-00861-5.
Meng TG#, Zhou Q#, Ma XS#, Liu XY#, Meng QR, Huang XJ, Liu HL, Lei WL, Zhao ZH, Ouyang YC, Hou Y, Schatten H, Ou XH*, Wang ZB*, Gao SR*, Sun QY*. PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome. Nat Commun. 2020 Dec 11;11(1):6354. doi: 10.1038/s41467-020-20242-9
Lei WL, Han F, Hu MW, Liang QX, Meng TG, Zhou Q, Ouyang YC, Hou Y, Schatten H, Wang ZB*, Sun QY*. Protein phosphatase 6 is a key factor regulating spermatogenesis. Cell Death Differ. 2020 Jun;27(6):1952-1964.
Zhao ZH, Li CY, Meng TG, Wang Y, Liu WB, Li A, Cai YJ, Hou Y, Schatten H, Wang ZB, Sun QY*, Sun Q* Single-cell RNA sequencing reveals regulation of fetal ovary development in the monkey (Macaca fascicularis). Cell Discov. 2020 Dec 29;6(1):97. doi: 10.1038/s41421-020-00219-0.
Zhao ZH, Ma JY, Meng TG, Wang ZB, Yue W, Zhou Q, Li S, Feng X, Hou Y, Schatten H, Ou XH*, Sun QY*. Single-cell RNA sequencing reveals the landscape of early female germ cell development. FASEB J. 2020 Jul 27. doi: 10.1096/fj.202001034RR. Wang Y, Li J, Dong F, Yue W, Ouyang YC, Wang ZB, Hou Y, Schatten H, Sun QY*. CENP-T regulates both the G2/M transition and anaphase entry by acting through CDH1 in meiotic oocytes. J Cell Sci. 2020 Feb 10;133(3):jcs238105. doi: 10.1242/jcs.238105.
Zhou Q, Li J, Yue W, Li A, Meng TG, Lei WL, Fan LH, Ouyang YC, Schatten H, Wang ZB, Sun QY*. Cell division cycle 23 is required for mouse oocyte meiotic maturation. FASEB J. 2020 Jul;34(7):8990-9002.
Han F, Dong MZ, Lei WL, Xu ZL, Gao F, Schatten H, Wang ZB, Sun XF*,Sun QY*. Oligoasthenoteratospermia and sperm tail bending in PPP4C-deficient mice. Mol Hum Reprod. 2020 Dec 30:gaaa083. doi: 10.1093/molehr/gaaa083.
Zhao ZH, Schatten H, Sun QY*. High throughput sequencing reveals landscapes of female germ cell development. Mol Hum Reprod. 2020 Aug 31:gaaa059. doi: 10.1093/molehr/gaaa059.
